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Intrinsic disorder in pathogen effectors: Protein flexibility as an evolutionary hallmark in a molecular arms race

MarĂ­n et al. (2013); The Plant Cell; 25: 3153-3157 (Ott lab)

15.08.2013

130814_id_effectors

Macarena Marín, Vladimir N. Uversky and Thomas Ott

A central paradigm of structural biology is that protein function depends on a fixed three-dimensional structure. This has been defied by the discovery of intrinsically disordered proteins, which lack a defined structure. Based on in silico proteome-wide surveys we discuss how disorder may contribute to function and evolution of effectors in the molecular arms race between hosts and pathogens.