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Antoine Porquier

Dr. Antoine Porquier

postdoc

Project description:

Botrytis cinerea is a necrotrophic fungal pathogen that induces the gray mold disease on more than 1,400 plant species. Intriguingly, B. cinerea produces small interfering RNAs as effectors (Bc-sRNAs) that invade plant cells during the infection process and hijack the RNA interference machinery of the host to silence important defense genes. Most of these Bc-sRNAs are encoded by retrotransposons and seem to be upregulated during infection of host plants. In my postdoctoral project, I am interested in understanding what are the regulatory cues of Bc-sRNA production on transcriptional and post-transcriptional levels. I am also interested in finding answers to the questions why and how a broad host spectrum pathogen such as B. cinerea produces Bc-sRNA effectors against diverse plant species.

 

CV:

Since 09/2017        Postdoc (with Alexander von Humboldt fellowship), LMU Munich (Institute of Genetics, Germany) “Elucidating the regulation and function of pathogen-produced host immune-suppressive small RNAs in the plant pathogen Botrytis cinerea”

10/2013-12/2016   PhD, INRA (BIOGER) of Thiverval-Grignon, France, supervised by Dr. Muriel VIAUD. “Study of the regulation mechanisms of secondary metabolism in the gray mold disease agent Botrytis cinerea.”

01/2013-06/2013   Master’s degree lab internship, Fungisem, University of Angers (France), supervised by Dr. Thomas Guillemette, “Responses of Alternaria brassicicola against the phytoalexins camalexin and brassinin”

09/2011-06/2013   Master’s degree, University of Angers (France), “Integrative vegetal biology, gene, plant and agrosystem” with specialization in phytopathology

06/2012-07/2012   Voluntary internship, University of Nottingham (UK), supervised by Dr. Simon Avery, “Phenotypic heterogeneity in yeast”

09/2008-06/2012   Bachelor’s degree in biology, University of Angers (France), specialization in plant biology and phytopathology

 

Publications:

Porquier, A, Morgant, G, Moraga, J, Dalmais, B, Luyten, I, Simon, A, Pradier, J-M, Amselem, J, Collado, IG, Viaud, M, (2016). The botrydial biosynthetic gene cluster of Botrytis cinerea displays a bipartite genomic structure and is positively regulated by the putative Zn(II)2Cys6 transcription factor BcBot6. Fungal Genet. Biol. 96, 33–46.

Viaud, M, Schumacher, J, Porquier, A, Simon, A, (2016). Regulation of Secondary Metabolism in the Gray Mold Fungus Botrytis cinerea. Host-Pathog. Interact. Microb. Metab. Pathog. Antiinfectives 201–216.

Schumacher, J, Simon, A, Cohrs, KC, Traeger, S, Porquier, A, Dalmais, B, Viaud, M, Tudzynski, B, (2015). The VELVET Complex in the Gray Mold Fungus Botrytis cinerea: Impact of BcLAE1 on Differentiation, Secondary Metabolism, and Virulence. Mol. Plant. Microbe Interact. 28, 659–674.